Conferencia "Machado - Guerreiro" Congenital Chagas’ disease in Chile: Incidence, Diagnosis and treatment evaluation by PCR
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Congenital Trypanosoma cruzi infection in neonates and infants from two regions of Chile where Chagas' disease is endemic.
Chagas’ disease, or American trypanosomiasis, whose etiological agent is the protozoan parasite Trypanosoma cruzi, is an important public health concern in Latin America. At least 8 million people acquired the infection via the arthropod vector or another mechanism of transmission, such as blood transfusion or vertical transmission from mother to child (9). In Chile (11), the parasitose is ende...
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One major goal of research on Chagas disease is the development of effective chemotherapy to eliminate the infection from individuals who have not yet developed cardiac and/or digestive disease manifestations. Cure evaluation is the more complex aspect of its treatment, often leading to diverse and controversial results. The absence of reliable methods or a diagnostic gold standard to assess et...
متن کاملVertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile: Preliminary Report (2005-2008).
Congenital Chagas disease acquired special importance in Chile after the certification of the control of Triatoma infestans and transmission by blood donors affected with Trypanosoma cruzi. In order to establish adequate protocols for intervention and control in infected mother-neonate pairs in endemic zones of Chagas disease, we present partial results (2005-2008) of a pilot project which is b...
متن کاملEvaluation of nifurtimox treatment of chronic Chagas disease by means of several parasitological methods.
Currently, evaluation of drug efficacy for Chagas disease remains a controversial issue with no consensus. In this work, we evaluated the parasitological efficacy of Nifurtimox treatment in 21 women with chronic Chagas disease from an area of endemicity in Chile who were treated according to current protocols. Under pre- and posttherapy conditions, blood (B) samples and xenodiagnosis (XD) sampl...
متن کاملT. cruzi OligoC-TesT: A Simplified and Standardized Polymerase Chain Reaction Format for Diagnosis of Chagas Disease
BACKGROUND PCR has evolved into one of the most promising tools for T. cruzi detection in the diagnosis and control of Chagas disease. However, general use of the technique is hampered by its complexity and the lack of standardization. METHODOLOGY We here present the development and phase I evaluation of the T. cruzi OligoC-TesT, a simple and standardized dipstick format for detection of PCR ...
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